Retinoic Acid Induces an IFN-Driven Inflammatory Tumour Microenvironment, Sensitizing to Immune Checkpoint Therapy

Retinoic Acid Induces an IFN-Driven Inflammatory Tumour Microenvironment, Sensitizing to Immune Checkpoint Therapy

With immune checkpoint therapy (ICT) having reshaped the treatment of many cancers, the next frontier is to identify and develop novel combination therapies to improve efficacy. Previously, we and others identified beneficial immunological effects of the vitamin A derivative tretinoin on anti-tumour...

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Bibliographic Details
Main Authors: Caitlin M. Tilsed, Thomas H. Casey, Emma de Jong, Anthony Bosco, Rachael M. Zemek, Joanne Salmons, Graeme Wan, Michael J. Millward, Anna K. Nowak, Richard A. Lake, Willem Joost Lesterhuis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Oncology
Subjects:
retinoic acid
immune checkpoint therapy
cancer
interferon
mesothelioma
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.849793/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.849793/full

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