Anti-myeloma activity of Akt inhibition is linked to the activation status of PI3K/Akt and MEK/ERK pathway.

Anti-myeloma activity of Akt inhibition is linked to the activation status of PI3K/Akt and MEK/ERK pathway.

The PI3K/Akt/mTOR signal transduction pathway plays a central role in multiple myeloma (MM) disease progression and development of therapeutic resistance. mTORC1 inhibitors have shown limited efficacy in the clinic, largely attributed to the reactivation of Akt due to rapamycin induced mTORC2 activi...

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Bibliographic Details
Main Authors: Vijay Ramakrishnan, Teresa Kimlinger, Jessica Haug, Utkarsh Painuly, Linda Wellik, Timothy Halling, S Vincent Rajkumar, Shaji Kumar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3503708?pdf=render

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http://europepmc.org/articles/PMC3503708?pdf=render

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