A novel class of C14-sulfonate-tetrandrine derivatives as potential chemotherapeutic agents for hepatocellular carcinoma

Hepatocellular carcinoma (HCC), the most common malignancy of the liver, exhibits high recurrence and metastasis. Structural modifications of natural products are crucial resources of antitumor drugs. This study aimed to synthesize C-14 derivatives of tetrandrine and evaluate their effects on HCC. F...

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Bibliographic Details
Main Authors: Taibai Jiang, Guangtong Xie, Zhirui Zeng, Junjie Lan, Hanfei Liu, Jinyu Li, Hai Ren, Tengxiang Chen, Weidong Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Chemistry
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.1107824/full