Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment
Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against infections and regulates the innate and acquired immune response. IL-18 is produced by both hematopoietic and non-hematopoietic cells, including monocytes, macrophages, keratinocytes and mesenchymal cell. I...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.919973/full |
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| author | Stella Amarachi Ihim Stella Amarachi Ihim Stella Amarachi Ihim Sharafudeen Dahiru Abubakar Sharafudeen Dahiru Abubakar Zeineb Zian Takanori Sasaki Takanori Sasaki Mohammad Saffarioun Shayan Maleknia Gholamreza Azizi |
| author_facet | Stella Amarachi Ihim Stella Amarachi Ihim Stella Amarachi Ihim Sharafudeen Dahiru Abubakar Sharafudeen Dahiru Abubakar Zeineb Zian Takanori Sasaki Takanori Sasaki Mohammad Saffarioun Shayan Maleknia Gholamreza Azizi |
| author_sort | Stella Amarachi Ihim |
| collection | DOAJ |
| description | Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against infections and regulates the innate and acquired immune response. IL-18 is produced by both hematopoietic and non-hematopoietic cells, including monocytes, macrophages, keratinocytes and mesenchymal cell. IL-18 could potentially induce inflammatory and cytotoxic immune cell activities leading to autoimmunity. Its elevated levels have been reported in the blood of patients with some immune-related diseases, including rheumatoid arthritis, systemic lupus erythematosus, type I diabetes mellitus, atopic dermatitis, psoriasis, and inflammatory bowel disease. In the present review, we aimed to summarize the biological properties of IL-18 and its pathological role in different autoimmune diseases. We also reported some monoclonal antibodies and drugs targeting IL-18. Most of these monoclonal antibodies and drugs have only produced partial effectiveness or complete ineffectiveness in vitro, in vivo and human studies. The ineffectiveness of these drugs targeting IL-18 may be largely due to the loophole caused by the involvement of other cytokines and proteins in the signaling pathway of many inflammatory diseases besides the involvement of IL-18. Combination drug therapies, that focus on IL-18 inhibition, in addition to other cytokines, are highly recommended to be considered as an important area of research that needs to be explored. |
| first_indexed | 2024-12-10T15:51:20Z |
| format | Article |
| id | doaj.art-19f845f9456d455fb276d12494ceb59d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T15:51:20Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-19f845f9456d455fb276d12494ceb59d2022-12-22T01:42:47ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.919973919973Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatmentStella Amarachi Ihim0Stella Amarachi Ihim1Stella Amarachi Ihim2Sharafudeen Dahiru Abubakar3Sharafudeen Dahiru Abubakar4Zeineb Zian5Takanori Sasaki6Takanori Sasaki7Mohammad Saffarioun8Shayan Maleknia9Gholamreza Azizi10Department of Molecular and Cellular Pharmacology, University of Shizuoka, Shizuoka, JapanDepartment of Pharmacology and Toxicology, University of Nigeria, Nsukka, NigeriaDepartment of Science Laboratory Technology, University of Nigeria, Nsukka, NigeriaDivision of Molecular Pathology, Research Institute for Biomedical Sciences, Tokyo University of Science, Tokyo, JapanDepartment of Medical Laboratory Science, College of Medical Science, Ahmadu Bello University, Zaria, NigeriaBiomedical Genomics and Oncogenetics Research Laboratory, Faculty of Sciences and Techniques of Tangier, Abdelmalek Essaadi University, Tetouan, MoroccoDivision of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesDivision of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, JapanBiopharmaceutical Research Center, AryoGen Pharmed Inc., Alborz University of Medical Sciences, Karaj, IranBiopharmaceutical Research Center, AryoGen Pharmed Inc., Alborz University of Medical Sciences, Karaj, Iran0Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, IranInterleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against infections and regulates the innate and acquired immune response. IL-18 is produced by both hematopoietic and non-hematopoietic cells, including monocytes, macrophages, keratinocytes and mesenchymal cell. IL-18 could potentially induce inflammatory and cytotoxic immune cell activities leading to autoimmunity. Its elevated levels have been reported in the blood of patients with some immune-related diseases, including rheumatoid arthritis, systemic lupus erythematosus, type I diabetes mellitus, atopic dermatitis, psoriasis, and inflammatory bowel disease. In the present review, we aimed to summarize the biological properties of IL-18 and its pathological role in different autoimmune diseases. We also reported some monoclonal antibodies and drugs targeting IL-18. Most of these monoclonal antibodies and drugs have only produced partial effectiveness or complete ineffectiveness in vitro, in vivo and human studies. The ineffectiveness of these drugs targeting IL-18 may be largely due to the loophole caused by the involvement of other cytokines and proteins in the signaling pathway of many inflammatory diseases besides the involvement of IL-18. Combination drug therapies, that focus on IL-18 inhibition, in addition to other cytokines, are highly recommended to be considered as an important area of research that needs to be explored.https://www.frontiersin.org/articles/10.3389/fimmu.2022.919973/fullinflammatory diseasesautoimmune diseasesinterleukin-18monoclonal antibodiesimmunity |
| spellingShingle | Stella Amarachi Ihim Stella Amarachi Ihim Stella Amarachi Ihim Sharafudeen Dahiru Abubakar Sharafudeen Dahiru Abubakar Zeineb Zian Takanori Sasaki Takanori Sasaki Mohammad Saffarioun Shayan Maleknia Gholamreza Azizi Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment Frontiers in Immunology inflammatory diseases autoimmune diseases interleukin-18 monoclonal antibodies immunity |
| title | Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment |
| title_full | Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment |
| title_fullStr | Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment |
| title_full_unstemmed | Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment |
| title_short | Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment |
| title_sort | interleukin 18 cytokine in immunity inflammation and autoimmunity biological role in induction regulation and treatment |
| topic | inflammatory diseases autoimmune diseases interleukin-18 monoclonal antibodies immunity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.919973/full |
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