Immunomodulatory Properties of DNA Hypomethylating Agents: Selecting the Optimal Epigenetic Partner for Cancer Immunotherapy

Immunomodulatory Properties of DNA Hypomethylating Agents: Selecting the Optimal Epigenetic Partner for Cancer Immunotherapy

DNA hypomethylating agents (DHAs) play a well-acknowledged role in potentiating the immunogenicity and the immune recognition of neoplastic cells. This immunomodulatory activity of DHAs is linked to their ability to induce or to up-regulate on neoplastic cells the expression of a variety of immune m...

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Bibliographic Details
Main Authors: Carolina Fazio, Alessia Covre, Ornella Cutaia, Maria Fortunata Lofiego, Patrizia Tunici, Carla Chiarucci, Sara Cannito, Gianluca Giacobini, James N. Lowder, Roberta Ferraldeschi, Pietro Taverna, Anna Maria Di Giacomo, Sandra Coral, Michele Maio
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Pharmacology
Subjects:
DNA hypomethylating agent
epigenetics
cancer
immune phenotype
immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01443/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01443/full

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