Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like <i>NFE2L2/PGC-1α</i> <i><sup>-/-</sup></i> Mouse Model Evoke Complement Component C5a Independent of C3

Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like <i>NFE2L2/PGC-1α</i> <i><sup>-/-</sup></i> Mouse Model Evoke Complement Component C5a Independent of C3

Aging-associated chronic oxidative stress and inflammation are known to be involved in various diseases, e.g., age-related macular degeneration (AMD). Previously, we reported the presence of dry AMD-like signs, such as elevated oxidative stress, dysfunctional mitophagy and the accumulation of detrim...

Full description

Bibliographic Details
Main Authors: Iswariyaraja Sridevi Gurubaran, Hanna Heloterä, Stephen Marry, Ali Koskela, Juha M. T. Hyttinen, Jussi J. Paterno, Arto Urtti, Mei Chen, Heping Xu, Anu Kauppinen, Kai Kaarniranta
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Biology
Subjects:
aging
oxidative stress
mitochondrial damage
age-related macular degeneration
inflammation
complement system
Online Access:https://www.mdpi.com/2079-7737/10/7/622

Internet

https://www.mdpi.com/2079-7737/10/7/622

Similar Items