Effects of amyloid-β on protein SUMOylation and levels of mitochondrial proteins in primary cortical neurons

Effects of amyloid-β on protein SUMOylation and levels of mitochondrial proteins in primary cortical neurons

Defining the molecular changes that underlie Alzheimer’s disease (AD) is an important question in neuroscience. Here, we examined changes in protein SUMOylation, and proteins involved in mitochondrial dynamics, in an in vitro model of AD induced by application of amyloid-β 1–42 (Aβ1–42) to cultured...

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Bibliographic Details
Main Authors: Ericks S. Soares, Ana C. Guerra de Souza, Camila A. Zanella, Ruth E. Carmichael, Jeremy M. Henley, Kevin A. Wilkinson, Helena I. Cimarosti
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:IBRO Neuroscience Reports
Subjects:
Alzheimer’s disease: amyloid-beta peptide
Dynamin related protein
Mitochondria
SENP3
SUMOylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2667242122000033

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http://www.sciencedirect.com/science/article/pii/S2667242122000033

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