Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma

Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma

Neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia, and glaucoma, affect millions of people worldwide. ALS is caused by the loss of motor neurons in the spinal cord, brainstem, and brain, and genetic mutations are responsible for 10% of all ALS cases....

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Bibliographic Details
Main Authors: Reka P. Toth, Julie D. Atkin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
optineurin
neuroinflammation
autophagy
vesicular trafficking
amyotrophic lateral sclerosis
glaucoma
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01017/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01017/full

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