Unlocking the post-transplant microenvironment for successful islet function and survival

Unlocking the post-transplant microenvironment for successful islet function and survival

Islet transplantation (IT) offers the potential to restore euglycemia for patients with type 1 diabetes mellitus (T1DM). Despite improvements in islet isolation techniques and immunosuppressive regimes, outcomes remain suboptimal with UK five-year graft survivals (5YGS) of 55% and most patients stil...

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Bibliographic Details
Main Authors: Daniel T. Doherty, Hussein A. Khambalia, David van Dellen, Rachel E. Jennings, Karen Piper Hanley
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Endocrinology
Subjects:
islet transplantation
extra-cellular matrix (ECM)
tissue response
beta-cell replacement
T1DM (type 1 diabetes mellitus)
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1250126/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1250126/full

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