A KLK4 proteinase substrate capture approach to antagonize PAR1

A KLK4 proteinase substrate capture approach to antagonize PAR1

Abstract Proteinase-activated receptor-1 (PAR1), triggered by thrombin and other serine proteinases such as tissue kallikrein-4 (KLK4), is a key driver of inflammation, tumor invasiveness and tumor metastasis. The PAR1 transmembrane G-protein-coupled receptor therefore represents an attractive targe...

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Bibliographic Details
Main Authors: Eitan Rabinovitch, Koishiro Mihara, Amiram Sananes, Marianna Zaretsky, Michael Heyne, Julia Shifman, Amir Aharoni, Morley D. Hollenberg, Niv Papo
Format: Article
Language:English
Published: Nature Portfolio 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-95666-4

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https://doi.org/10.1038/s41598-021-95666-4

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