Use of the KlADH3 promoter for the quantitative production of the murine PDE5A isoforms in the yeast Kluyveromyces lactis

Use of the KlADH3 promoter for the quantitative production of the murine PDE5A isoforms in the yeast Kluyveromyces lactis

Abstract Background Phosphodiesterases (PDE) are a superfamily of enzymes that hydrolyse cyclic nucleotides (cAMP/cGMP), signal molecules in transduction pathways regulating crucial aspects of cell life. PDEs regulate the intensity and duration of the cyclic nucleotides signal modulating the downstr...

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Bibliographic Details
Main Authors: Silvia Cardarelli, Mauro Giorgi, Fabio Naro, Francesco Malatesta, Stefano Biagioni, Michele Saliola
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Microbial Cell Factories
Subjects:
Kluyveromyces lactis
KlADH3 promoter
Multicopy plasmids
Murine PDE5
cGMP
Sildenafil
Online Access:http://link.springer.com/article/10.1186/s12934-017-0779-5

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http://link.springer.com/article/10.1186/s12934-017-0779-5

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