The Prognostic Impact of Intratumoral Aryl Hydrocarbon Receptor in Primary Breast Cancer Depends on the Type of Endocrine Therapy: A Population-Based Cohort Study

The Prognostic Impact of Intratumoral Aryl Hydrocarbon Receptor in Primary Breast Cancer Depends on the Type of Endocrine Therapy: A Population-Based Cohort Study

The aryl hydrocarbon receptor (AhR) is a master regulator of multiple pathways involved in breast cancer, and influences the estrogen receptor alpha (ER) and aromatase/CYP19A1. The purpose of this study was to elucidate the interplay between intratumoral levels of AhR and aromatase, patient characte...

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Bibliographic Details
Main Authors: Helga Tryggvadottir, Emma Sandén, Sofie Björner, Alessandra Bressan, Maria Ygland Rödström, Somayeh Khazaei, Dean P. Edwards, Björn Nodin, Karin Jirström, Karolin Isaksson, Signe Borgquist, Helena Jernström
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
breast cancer
aryl hydrocarbon receptor
intratumoral aromatase
endocrine therapy
polymorphisms
prognosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.642768/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.642768/full

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