Development of selective non-peptide angiotensin II type 2 receptor agonsists
The development of the first drug-like selective angiotensin II type 2 (AT 2 ) receptor agonist (22) derived from the non-selective angiotensin II type 1 (AT 1 ) receptor/AT 2 receptor agonist L-162,313 is presented. Compound 22 with a K i value of 0.4 nM for the AT 2 receptor and a K i > 10 μM f...
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| Format: | Article |
| Language: | English |
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SAGE Publications
2010-03-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320309347790 |