The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia

The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia

Background PI3K/AKT pathway mutations are found in T-cell acute lymphoblastic leukemia, but their overall impact and associations with other genetic aberrations is unknown. PTEN mutations have been proposed as secondary mutations that follow NOTCH1-activating mutations and cause cellular resistance...

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Main Authors: Linda Zuurbier, Emanuel F. Petricoin, Maartje J. Vuerhard, Valerie Calvert, Clarissa Kooi, Jessica G.C.A.M. Buijs-Gladdines, Willem K. Smits, Edwin Sonneveld, Anjo J.P. Veerman, Willem A. Kamps, Martin Horstmann, Rob Pieters, Jules P.P. Meijerink
Format: Article
Language:English
Published: Ferrata Storti Foundation 2012-09-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/6412

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https://haematologica.org/article/view/6412

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