Bcl2-A1 interacts with pro-caspase-3: Implications for amyotrophic lateral sclerosis

Bcl2-A1 interacts with pro-caspase-3: Implications for amyotrophic lateral sclerosis

Expression of mutant SOD1 typical of familial amyotrophic lateral sclerosis (ALS) induces the expression of Bcl2-A1, a member of the Bcl2 family of proteins, specifically in motor neurons of transgenic mice.In this work, we have used immortalized motor neurons (NSC-34) and transgenic mice expressing...

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Bibliographic Details
Main Authors: Ciro Iaccarino, Maria Elena Mura, Sonia Esposito, Franco Carta, Giovanna Sanna, Franco Turrini, Maria Teresa Carrì, Claudia Crosio
Format: Article
Language:English
Published: Elsevier 2011-09-01
Series:Neurobiology of Disease
Subjects:
ALS
Apoptosis
Pro-caspase-3
Bcl2-A1
Mutant SOD1
NSC34 cells
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111001690

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http://www.sciencedirect.com/science/article/pii/S0969996111001690

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