Divalent magnesium restores cytoskeletal storage lesions in cold-stored platelet concentrates

Abstract Cold storage of platelet concentrates (PC) has become attractive due to the reduced risk of bacterial proliferation, but in vivo circulation time of cold-stored platelets is reduced. Ca2+ release from storage organelles and higher activity of Ca2+ pumps at temperatures < 15 °C triggers c...

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Bibliographic Details
Main Authors: Konstanze Aurich, Jan Wesche, Martin Ulbricht, Oliver Otto, Andreas Greinacher, Raghavendra Palankar
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-10231-x