Retinal protection by fungal product theissenolactone B in a sodium iodate-induced AMD model through targeting retinal pigment epithelial matrix metalloproteinase-9 and microglia activity

Age-related macular degeneration (AMD) is the leading cause of low vision and blindness for which there is currently no cure. Increased matrix metalloproteinase-9 (MMP-9) was found in AMD and potently contributes to its pathogenesis. Resident microglia also promote the processes of chronic neuroinfl...

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Bibliographic Details
Main Authors: Fan-Li Lin, Yu-Wen Cheng, Li-Huei Chen, Jau-Der Ho, Jing-Lun Yen, Mong-Heng Wang, Tzong-Huei Lee, George Hsiao
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222201527X