The Affinity of Elongated Membrane-Tethered Ligands Determines Potency of T Cell Receptor Triggering

The Affinity of Elongated Membrane-Tethered Ligands Determines Potency of T Cell Receptor Triggering

T lymphocytes are important mediators of adoptive immunity but the mechanism of T cell receptor (TCR) triggering remains uncertain. The interspatial distance between engaged T cells and antigen-presenting cells (APCs) is believed to be important for topological rearrangement of membrane tyrosine pho...

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Bibliographic Details
Main Authors: Bing-Mae Chen, Mohammad Ameen Al-Aghbar, Chien-Hsin Lee, Tien-Ching Chang, Yu-Cheng Su, Ya-Chen Li, Shih-En Chang, Chin-Chuan Chen, Tsai-Hua Chung, Yuan-Chun Liao, Chau-Hwang Lee, Steve R. Roffler
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Immunology
Subjects:
affinity
T cell receptor triggering
artificial antigen-presenting cell
pMHC
anti-CD3 scFv
OKT3
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00793/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.00793/full

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