APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses

APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses

The amyloid precursor protein (APP), whose mutations cause familial Alzheimer’s disease, interacts with the synaptic release machinery, suggesting a role in neurotransmission. Here we mapped this interaction to the NH2-terminal region of the APP intracellular domain. A peptide encompassing this bind...

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Bibliographic Details
Main Authors: Tomas Fanutza, Dolores Del Prete, Michael J Ford, Pablo E Castillo, Luciano D’Adamio
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-11-01
Series:eLife
Subjects:
neurodegeneration
synaptic transmission
Amyloid precursor protein
synaptic vesicle
Dementia
Online Access:https://elifesciences.org/articles/09743

Internet

https://elifesciences.org/articles/09743

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