Improvement of NASH and liver fibrosis through modulation of the gut-liver axis by a novel intestinal FXR agonist

Improvement of NASH and liver fibrosis through modulation of the gut-liver axis by a novel intestinal FXR agonist

Farnesoid X receptor (FXR) plays a pivotal role in the regulation of bile acid homeostasis and is involved in the pathogenesis of nonalcoholic steatohepatitis (NASH). Although FXR agonists effectively alleviate pathological features of NASH, adverse effects such as disturbance of cholesterol homeost...

Full description

Bibliographic Details
Main Authors: An-Na Moon, François Briand, Natalia Breyner, Dong-Keun Song, Martin Rønn Madsen, Hongbin Kim, Keonwoo Choi, Yoonsuk Lee, Wan Namkung
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
NASH
FXR
Gut
Bile acid
Microbiota
Pruritus
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224002154

Internet

http://www.sciencedirect.com/science/article/pii/S0753332224002154

Similar Items