A muscle‐specific MuRF1‐E2 network requires stabilization of MuRF1‐E2 complexes by telethonin, a newly identified substrate

A muscle‐specific MuRF1‐E2 network requires stabilization of MuRF1‐E2 complexes by telethonin, a newly identified substrate

Abstract Background Muscle wasting is observed in the course of many diseases and also during physiological conditions (disuse, ageing). Skeletal muscle mass is largely controlled by the ubiquitin‐proteasome system and thus by the ubiquitinating enzymes (E2s and E3s) that target substrates for subse...

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Bibliographic Details
Main Authors: Cécile Polge, Stéphanie Cabantous, Christiane Deval, Agnès Claustre, Antoine Hauvette, Catherine Bouchenot, Julien Aniort, Daniel Béchet, Lydie Combaret, Didier Attaix, Daniel Taillandier
Format: Article
Language:English
Published: Wiley 2018-02-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
E3 ubiquitin ligase
muscle wasting
ubiquitin‐conjugating enzyme
UBE2
Tcap
split‐GFP
Online Access:https://doi.org/10.1002/jcsm.12249

Internet

https://doi.org/10.1002/jcsm.12249

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