SARS-CoV-2 Spike Protein Intensifies Cerebrovascular Complications in Diabetic hACE2 Mice through RAAS and TLR Signaling Activation

SARS-CoV-2 Spike Protein Intensifies Cerebrovascular Complications in Diabetic hACE2 Mice through RAAS and TLR Signaling Activation

Diabetics are more vulnerable to SARS-CoV-2 neurological manifestations. The molecular mechanisms of SARS-CoV-2-induced cerebrovascular dysfunction in diabetes are unclear. We hypothesize that SARS-CoV-2 exacerbates diabetes-induced cerebrovascular oxidative stress and inflammation via activation of...

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Bibliographic Details
Main Authors: Faith N. Burnett, Maha Coucha, Deanna R. Bolduc, Veronica C. Hermanns, Stan P. Heath, Maryam Abdelghani, Lilia Z. Macias-Moriarity, Mohammed Abdelsaid
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
SARS-CoV-2 spike protein
diabetes
hACE2 KI mice
cerebrovasculature
RAAS
TLR signaling
Online Access:https://www.mdpi.com/1422-0067/24/22/16394

Internet

https://www.mdpi.com/1422-0067/24/22/16394

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