YY1 downregulation underlies therapeutic response to molecular targeted agents
Abstract During targeted treatment, oncogene-addicted tumor cells often evolve from an initial drug-sensitive state through a drug-tolerant persister bottleneck toward the ultimate emergence of drug-resistant clones. The molecular basis underlying this therapy-induced evolutionary trajectory has not...
Main Authors: | , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2024-11-01
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Series: | Cell Death and Disease |
Online Access: | https://doi.org/10.1038/s41419-024-07239-8 |