Ghrelin octanoylation by ghrelin O-acyltransferase: protein acylation impacting metabolic and neuroendocrine signalling

The acylated peptide hormone ghrelin impacts a wide range of physiological processes but is most well known for controlling hunger and metabolic regulation. Ghrelin requires a unique posttranslational modification, serine octanoylation, to bind and activate signalling through its cognate GHS-R1a rec...

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Bibliographic Details
Main Authors: Tasha R. Davis, Mariah R. Pierce, Sadie X. Novak, James L. Hougland
Format: Article
Language:English
Published: The Royal Society 2021-07-01
Series:Open Biology
Subjects:
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.210080