Regulation of N-type calcium channels by nociceptin receptors and its possible role in neurological disorders

Regulation of N-type calcium channels by nociceptin receptors and its possible role in neurological disorders

Abstract Activation of nociceptin opioid peptide receptors (NOP, a.k.a. opioid-like receptor-1, ORL-1) by the ligand nociceptin/orphanin FQ, leads to G protein-dependent regulation of Cav2.2 (N-type) voltage-gated calcium channels (VGCCs). This typically causes a reduction in calcium currents, trigg...

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Bibliographic Details
Main Authors: Emanuelle Sistherenn Caminski, Flavia Tasmin Techera Antunes, Ivana Assis Souza, Eliane Dallegrave, Gerald W. Zamponi
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Molecular Brain
Subjects:
Anxiety
Learning
ORL-1
Opioid receptor
Pain
G protein-coupled receptor
Online Access:https://doi.org/10.1186/s13041-022-00982-z

Internet

https://doi.org/10.1186/s13041-022-00982-z

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