Cerebellar neuronal dysfunction accompanies early motor symptoms in spinocerebellar ataxia type 3

Cerebellar neuronal dysfunction accompanies early motor symptoms in spinocerebellar ataxia type 3

Spinocerebellar ataxia type 3 (SCA3) is an adult-onset, progressive ataxia. SCA3 presents with ataxia before any gross neuropathology. A feature of many cerebellar ataxias is aberrant cerebellar output that contributes to motor dysfunction. We examined whether abnormal cerebellar output was present...

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Bibliographic Details
Main Authors: Kristin Mayoral-Palarz, Andreia Neves-Carvalho, Sara Duarte-Silva, Daniela Monteiro-Fernandes, Patrícia Maciel, Kamran Khodakhah
Format: Article
Language:English
Published: The Company of Biologists 2022-08-01
Series:Disease Models & Mechanisms
Subjects:
cerebellum
ataxia
sca3
purkinje cells
Online Access:http://dmm.biologists.org/content/15/8/dmm049514

Internet

http://dmm.biologists.org/content/15/8/dmm049514

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