Case report: Transfusion independence and abolition of extravascular hemolysis in a PNH patient treated with pegcetacoplan

Case report: Transfusion independence and abolition of extravascular hemolysis in a PNH patient treated with pegcetacoplan

More than half of patients with paroxysmal nocturnal hemoglobinuria (PNH) treated with complement fraction C5 inhibitors experience residual anemia and hemolysis. This is partly due to the persistent activation of the complement cascade upstream C5, resulting in C3 deposition on PNH erythrocytes and...

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Bibliographic Details
Main Authors: Bruno Fattizzo, Francesco Versino, Anna Zaninoni, Anna Paola Maria Luisa Marcello, Cristina Vercellati, Silvia Artuso, Wilma Barcellini
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
pegcetacoplan
paroxysmal nocturnal hemoglobinuria
extravascular hemolysis
direct antiglobulin test
ektacytometry
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1060923/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1060923/full

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