Structural and functional specificity of H3K36 methylation

Structural and functional specificity of H3K36 methylation

Abstract The methylation of histone H3 at lysine 36 (H3K36me) is essential for maintaining genomic stability. Indeed, this methylation mark is essential for proper transcription, recombination, and DNA damage response. Loss- and gain-of-function mutations in H3K36 methyltransferases are closely link...

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Bibliographic Details
Main Authors: Ulysses Tsz Fung Lam, Bryan Kok Yan Tan, John Jia Xin Poh, Ee Sin Chen
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Epigenetics & Chromatin
Subjects:
Set2
SETD2
NSD2
NSD3
ASH1L
H3K36
Online Access:https://doi.org/10.1186/s13072-022-00446-7

Internet

https://doi.org/10.1186/s13072-022-00446-7

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