Photodegradation of the H<sub>1</sub> Antihistaminic Topical Drugs Emedastine, Epinastine, and Ketotifen and ROS Tests for Estimations of Their Potent Phototoxicity

Photodegradation of the H<sub>1</sub> Antihistaminic Topical Drugs Emedastine, Epinastine, and Ketotifen and ROS Tests for Estimations of Their Potent Phototoxicity

In this study, important H<sub>1</sub> antihistaminic drugs, i.e., emedastine (EME), epinastine (EPI), and ketotifen (KET), were irradiated with UV/Vis light (300–800 nm) in solutions of different pH values. Next, they were analyzed by new high performance liquid chromatography (HPLC) me...

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Bibliographic Details
Main Authors: Anna Gumieniczek, Anna Berecka-Rycerz, Urszula Hubicka, Paweł Żmudzki, Karolina Lejwoda, Paweł Kozyra
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Pharmaceutics
Subjects:
H<sub>1</sub> antihistaminics
topical formulations
photodegradation kinetics
photodegradation pathways
phototoxicity
reactive oxygen species
Online Access:https://www.mdpi.com/1999-4923/12/6/560

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https://www.mdpi.com/1999-4923/12/6/560

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