A Rapid Screening Assay for Clarithromycin-Resistant Mycobacterium avium Complex Using Melting Curve Analysis with Nonfluorescent Labeled Probes

A Rapid Screening Assay for Clarithromycin-Resistant Mycobacterium avium Complex Using Melting Curve Analysis with Nonfluorescent Labeled Probes

ABSTRACT Mycobacterium avium complex (MAC) thrives in various environments and mainly causes lung disease in humans. Because macrolide antibiotics such as clarithromycin or azithromycin are key drugs for MAC lung disease, the emergence of macrolide-resistant strains prevents the treatment of MAC. Mo...

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Bibliographic Details
Main Authors: Akira Aoki, Hideto Jinno, Kenji Ogawa, Taku Nakagawa, Takayuki Inagaki, Takeaki Wajima, Yoshinori Okamoto, Kei-ichi Uchiya
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
Mycobacterium avium complex
clarithromycin resistance
melting curve analysis
nonfluorescent labeled probe
23S ribosomal RNA
rapid test
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04326-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.04326-22

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