The downregulation of tight junction proteins and pIgR in the colonic epithelium causes the susceptibility of EpCAM+/− mice to colitis and gut microbiota dysbiosis

The downregulation of tight junction proteins and pIgR in the colonic epithelium causes the susceptibility of EpCAM+/− mice to colitis and gut microbiota dysbiosis

BackgroundThe genetic factors play important roles on the pathogenesis of inflammatory bowel disease (IBD). EpCAM is highly expressed in the intestinal epithelium. It is still unclear if the decrease or somatic mutation of EpCAM could cause IBD.MethodsThe WT and EpCAM+/− mice were administrated with...

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Bibliographic Details
Main Authors: Ya Nie, Ting Lin, Yanhong Yang, Wanwan Liu, Qing Hu, Guibin Chen, Li Huang, Huijuan Wu, Cunjie Kong, Zili Lei, Jiao Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
EpCAM
inflammatory bowel disease
tight junction
pIgR
gut microbiota
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2024.1442611/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2024.1442611/full

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