Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids

Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids

Glucocorticoids are metabolized by the CYP3A isoform of cytochrome P450 and by 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1). Experimental data suggest that post-traumatic stress disorder (PTSD) is associated with an increase in hepatic 11β-HSD-1 activity and a concomitant decrease in hepatic...

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Bibliographic Details
Main Authors: Vadim E. Tseilikman, Julia O. Fedotova, Olga B. Tseilikman, Jurica Novak, Marina N. Karpenko, Victoria A. Maistrenko, Svetlana S. Lazuko, Lyudmila E. Belyeva, Mustapha Kamel, Alexey V. Buhler, Elena G. Kovaleva
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
PTSD
<i>trans</i>-resveratrol
glucocorticoids
anxiety
CYP3A
11-β-hydroxysteroid dehydrogenase type 1
Online Access:https://www.mdpi.com/1422-0067/24/11/9333

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https://www.mdpi.com/1422-0067/24/11/9333

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