Mechanism of action, potency and efficacy: considerations for cell therapies

Mechanism of action, potency and efficacy: considerations for cell therapies

Abstract One of the most challenging aspects of developing advanced cell therapy products (CTPs) is defining the mechanism of action (MOA), potency and efficacy of the product. This perspective examines these concepts and presents helpful ways to think about them through the lens of metrology. A log...

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Bibliographic Details
Main Authors: Carl G. Simon, Erich H. Bozenhardt, Christina M. Celluzzi, David Dobnik, Melanie L. Grant, Uma Lakshmipathy, Thiana Nebel, Linda Peltier, Anthony Ratcliffe, James L. Sherley, Glyn N. Stacey, Rouzbeh R. Taghizadeh, Eddie H. P. Tan, Sandrine Vessillier
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Journal of Translational Medicine
Subjects:
Cell therapy product
Efficacy
Efficacy endpoint
Efficacy endpoint test
Mechanism of action
Potency
Online Access:https://doi.org/10.1186/s12967-024-05179-7

Internet

https://doi.org/10.1186/s12967-024-05179-7

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