T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection.

T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection.

CD8(+) T cell exhaustion represents a major hallmark of chronic HIV infection. Two key transcription factors governing CD8(+) T cell differentiation, T-bet and Eomesodermin (Eomes), have previously been shown in mice to differentially regulate T cell exhaustion in part through direct modulation of P...

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Bibliographic Details
Main Authors: Marcus Buggert, Johanna Tauriainen, Takuya Yamamoto, Juliet Frederiksen, Martin A Ivarsson, Jakob Michaëlsson, Ole Lund, Bo Hejdeman, Marianne Jansson, Anders Sönnerborg, Richard A Koup, Michael R Betts, Annika C Karlsson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-07-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4102564?pdf=render

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http://europepmc.org/articles/PMC4102564?pdf=render

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