Apc mutation enhances PyMT-induced mammary tumorigenesis.
The Adenomatous Polyposis Coli (APC) tumor suppressor gene is silenced by hypermethylation or mutated in up to 70% of human breast cancers. In mouse models, Apc mutation disrupts normal mammary development and predisposes to mammary tumor formation; however, the cooperation between APC and other mut...
| Auteurs principaux: | , , , |
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| Format: | Article |
| Langue: | English |
| Publié: |
Public Library of Science (PLoS)
2011-01-01
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| Collection: | PLoS ONE |
| Accès en ligne: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22216254/?tool=EBI |