A Network of Serum Proteins Predict the Need for Systemic Immunomodulatory Therapy at Diagnosis in Noninfectious Uveitis

A Network of Serum Proteins Predict the Need for Systemic Immunomodulatory Therapy at Diagnosis in Noninfectious Uveitis

Purpose: Early identification of patients with noninfectious uveitis requiring steroid-sparing immunomodulatory therapy (IMT) is currently lacking in objective molecular biomarkers. We evaluated the proteomic signature of patients at the onset of disease and associated proteomic clusters with the ne...

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Main Authors: Jonas J.W. Kuiper, PhD, Fleurieke H. Verhagen, MD, PhD, Sanne Hiddingh, MSc, Roos A.W. Wennink, MD, Anna M. Hansen, PhD, Kerry A. Casey, PhD, Imo E. Hoefer, PhD, Saskia Haitjema, PhD, Julia Drylewicz, PhD, Mehmet Yakin, MD, H. Nida Sen, MD, PhD, Timothy R.D. J. Radstake, MD, PhD, Joke H. de Boer, MD, PhD
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Ophthalmology Science
Subjects:
Network-based medicine
Neutrophils
Noninfectious uveitis
Proteomics
Systemic immunomodulatory therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2666914522000641

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http://www.sciencedirect.com/science/article/pii/S2666914522000641

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