Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2*

Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2*

Sphingosine 1-phosphate (S1P), a bioactive lipid mediator, stimulates proliferation and contractility in hepatic stellate cells, the principal matrix-producing cells in the liver, and inhibits proliferation via S1P receptor 2 (S1P2) in hepatocytes in rats in vitro. A potential role of S1P and S1P2 i...

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Bibliographic Details
Main Authors: Hitoshi Ikeda, Naoko Watanabe, Isao Ishii, Tatsuo Shimosawa, Yukio Kume, Tomoaki Tomiya, Yukiko Inoue, Takako Nishikawa, Natsuko Ohtomo, Yasushi Tanoue, Satoko Iitsuka, Ryoto Fujita, Masao Omata, Jerold Chun, Yutaka Yatomi
Format: Article
Language:English
Published: Elsevier 2009-03-01
Series:Journal of Lipid Research
Subjects:
liver regeneration
liver fibrosis
hepatocyte
hepatic stellate cell
hepatic myofibroblast
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520308981

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http://www.sciencedirect.com/science/article/pii/S0022227520308981

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