Structure-Based Peptide Inhibitor Design of Amyloid-β Aggregation

Structure-Based Peptide Inhibitor Design of Amyloid-β Aggregation

Many human neurodegenerative diseases are associated with amyloid fibril formation. Inhibition of amyloid formation is of importance for therapeutics of the related diseases. However, the development of selective potent amyloid inhibitors remains challenging. Here based on the structures of amyloid...

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Bibliographic Details
Main Authors: Jinxia Lu, Qin Cao, Chuchu Wang, Jing Zheng, Feng Luo, Jingfei Xie, Yichen Li, Xiaojuan Ma, Lin He, David Eisenberg, James Nowick, Lin Jiang, Dan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neurodegenerative diseases
Alzheimer’s disease
Aβ fibril
protein misfolding
structure-based inhibitor design
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00054/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00054/full

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