Structural basis for transcription initiation by bacterial ECF σ factors
Extra-cytoplasmic function (ECF) σ factors allow bacteria to rapidly respond to stress conditions. Here the authors provide insights into the mechanism of bacterial stress-induced transcription by determining the crystal structures of the M. tuberculosis ECF σ factor bound RNA Polymerase (RNAP) holo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09096-y |
| _version_ | 1818431237753143296 |
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| author | Lingting Li Chengli Fang Ningning Zhuang Tiantian Wang Yu Zhang |
| author_facet | Lingting Li Chengli Fang Ningning Zhuang Tiantian Wang Yu Zhang |
| author_sort | Lingting Li |
| collection | DOAJ |
| description | Extra-cytoplasmic function (ECF) σ factors allow bacteria to rapidly respond to stress conditions. Here the authors provide insights into the mechanism of bacterial stress-induced transcription by determining the crystal structures of the M. tuberculosis ECF σ factor bound RNA Polymerase (RNAP) holoenzyme and the ECF σ factor-RNAP transcription initiation complex. |
| first_indexed | 2024-12-14T15:46:07Z |
| format | Article |
| id | doaj.art-1a58aa4b88894a5ead7026afa2e00b8e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T15:46:07Z |
| publishDate | 2019-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1a58aa4b88894a5ead7026afa2e00b8e2022-12-21T22:55:29ZengNature PortfolioNature Communications2041-17232019-03-0110111410.1038/s41467-019-09096-yStructural basis for transcription initiation by bacterial ECF σ factorsLingting Li0Chengli Fang1Ningning Zhuang2Tiantian Wang3Yu Zhang4Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of SciencesKey Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of SciencesKey Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of SciencesKey Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of SciencesKey Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of SciencesExtra-cytoplasmic function (ECF) σ factors allow bacteria to rapidly respond to stress conditions. Here the authors provide insights into the mechanism of bacterial stress-induced transcription by determining the crystal structures of the M. tuberculosis ECF σ factor bound RNA Polymerase (RNAP) holoenzyme and the ECF σ factor-RNAP transcription initiation complex.https://doi.org/10.1038/s41467-019-09096-y |
| spellingShingle | Lingting Li Chengli Fang Ningning Zhuang Tiantian Wang Yu Zhang Structural basis for transcription initiation by bacterial ECF σ factors Nature Communications |
| title | Structural basis for transcription initiation by bacterial ECF σ factors |
| title_full | Structural basis for transcription initiation by bacterial ECF σ factors |
| title_fullStr | Structural basis for transcription initiation by bacterial ECF σ factors |
| title_full_unstemmed | Structural basis for transcription initiation by bacterial ECF σ factors |
| title_short | Structural basis for transcription initiation by bacterial ECF σ factors |
| title_sort | structural basis for transcription initiation by bacterial ecf σ factors |
| url | https://doi.org/10.1038/s41467-019-09096-y |
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