Activation of CRH receptor type 1 expressed on glutamatergic neurons increases excitability of CA1 pyramidal neurons by the modulation of voltage-gated ion channels

Activation of CRH receptor type 1 expressed on glutamatergic neurons increases excitability of CA1 pyramidal neurons by the modulation of voltage-gated ion channels

Corticotropin-releasing hormone (CRH) plays an important role in a substantial number of patients with stress-related mental disorders, such as anxiety disorders and depression. CRH has been shown to increase neuronal excitability in the hippocampus, but the underlying mechanisms are poorly understo...

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Bibliographic Details
Main Authors: Stephan eKratzer, Corinna eMattusch, Michael eNoll-Hussong, Matthias eEder, Karl W. Kafitz, Michael W. Metzger, Nina eDedic, Jan M Deussing, Florian eHolsboer, Eberhard eKochs, Gerhard eRammes
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Potassium Channels
Protein Kinases
CRH
Neuronal excitability
CRH receptor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00091/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00091/full

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