High-Throughput Flow Cytometry Screening Reveals a Role for Junctional Adhesion Molecule A as a Cancer Stem Cell Maintenance Factor

High-Throughput Flow Cytometry Screening Reveals a Role for Junctional Adhesion Molecule A as a Cancer Stem Cell Maintenance Factor

Stem cells reside in niches that regulate the balance between self-renewal and differentiation. The identity of a stem cell is linked with the ability to interact with its niche through adhesion mechanisms. To identify targets that disrupt cancer stem cell (CSC) adhesion, we performed a flow cytomet...

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Bibliographic Details
Main Authors: Justin D. Lathia, Meizhang Li, Maksim Sinyuk, Alvaro G. Alvarado, William A. Flavahan, Kevin Stoltz, Ann Mari Rosager, James Hale, Masahiro Hitomi, Joseph Gallagher, Qiulian Wu, Jody Martin, Jason G. Vidal, Ichiro Nakano, Rikke H. Dahlrot, Steinbjørn Hansen, Roger E. McLendon, Andrew E. Sloan, Shideng Bao, Anita B. Hjelmeland, Christian T. Carson, Ulhas P. Naik, Bjarne Kristensen, Jeremy N. Rich
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713007274

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http://www.sciencedirect.com/science/article/pii/S2211124713007274

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