High-Throughput Flow Cytometry Screening Reveals a Role for Junctional Adhesion Molecule A as a Cancer Stem Cell Maintenance Factor
Stem cells reside in niches that regulate the balance between self-renewal and differentiation. The identity of a stem cell is linked with the ability to interact with its niche through adhesion mechanisms. To identify targets that disrupt cancer stem cell (CSC) adhesion, we performed a flow cytomet...
Main Authors: | Justin D. Lathia, Meizhang Li, Maksim Sinyuk, Alvaro G. Alvarado, William A. Flavahan, Kevin Stoltz, Ann Mari Rosager, James Hale, Masahiro Hitomi, Joseph Gallagher, Qiulian Wu, Jody Martin, Jason G. Vidal, Ichiro Nakano, Rikke H. Dahlrot, Steinbjørn Hansen, Roger E. McLendon, Andrew E. Sloan, Shideng Bao, Anita B. Hjelmeland, Christian T. Carson, Ulhas P. Naik, Bjarne Kristensen, Jeremy N. Rich |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2014-01-01
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Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124713007274 |
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