Trelagliptin relieved cognitive impairment of diabetes mellitus rats: Involvement of PI3K/Akt/GSK-3β and inflammation pathway

Trelagliptin relieved cognitive impairment of diabetes mellitus rats: Involvement of PI3K/Akt/GSK-3β and inflammation pathway

Cognitive impairment frequently coexists with diabetes. Trelagliptin is a once-weekly taking selective dipeptidyl peptidase-4 (DPP-4) inhibitor and a long-term effective hypoglycemic medicine; nonetheless, its effects for the treatment of diabetes-related cognitive impairment have only sometimes bee...

Full description

Bibliographic Details
Main Authors: Min Lei, Xiying Guo, Yue Yao, Ting Shu, Zhanhong Ren, Xiaosong Yang, Changhan Ouyang, Qingjie Chen, Chao Liu, Xiufen Liu
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Experimental Gerontology
Subjects:
Trelagliptin
Diabetes mellitus
Cognitive impairment
Learning and memory
Inflammation
Synaptic plasticity
Online Access:http://www.sciencedirect.com/science/article/pii/S0531556523002280

Internet

http://www.sciencedirect.com/science/article/pii/S0531556523002280

Similar Items