Trelagliptin relieved cognitive impairment of diabetes mellitus rats: Involvement of PI3K/Akt/GSK-3β and inflammation pathway

Trelagliptin relieved cognitive impairment of diabetes mellitus rats: Involvement of PI3K/Akt/GSK-3β and inflammation pathway

Cognitive impairment frequently coexists with diabetes. Trelagliptin is a once-weekly taking selective dipeptidyl peptidase-4 (DPP-4) inhibitor and a long-term effective hypoglycemic medicine; nonetheless, its effects for the treatment of diabetes-related cognitive impairment have only sometimes bee...

Full description

Bibliographic Details
Main Authors:	Min Lei, Xiying Guo, Yue Yao, Ting Shu, Zhanhong Ren, Xiaosong Yang, Changhan Ouyang, Qingjie Chen, Chao Liu, Xiufen Liu
Format:	Article
Language:	English
Published:	Elsevier 2023-10-01
Series:	Experimental Gerontology
Subjects:	Trelagliptin Diabetes mellitus Cognitive impairment Learning and memory Inflammation Synaptic plasticity
Online Access:	http://www.sciencedirect.com/science/article/pii/S0531556523002280

Similar Items

Tirzepatide ameliorates spatial learning and memory impairment through modulation of aberrant insulin resistance and inflammation response in diabetic rats
by: Xiying Guo, et al.
Published: (2023-08-01)

“Olfactory three-needle” acupuncture enhances synaptic function in A𝜷1-42-induced Alzheimer’s disease via activating PI3K/AKT/GSK-3𝜷 signaling pathway
by: Yuan Wang, et al.
Published: (2021-03-01)

PI3K/AKT signaling pathway: Molecular mechanisms and therapeutic potential in depression
by: Ningning Guo, et al.
Published: (2024-08-01)

Neurological functions of the masterswitch protein kinase – GSK-3
by: Oksana eKaidanovich-Beilin, et al.
Published: (2012-04-01)

BMAL1 ameliorates type 2 diabetes-induced cognitive impairment via AREG upregulation and PI3K/Akt/GSK-3β pathway activation
by: Jialu Xu, et al.
Published: (2025-01-01)

Neuroprotective potential of ketamine prevents developing brain structure impairment and alteration of neurocognitive function induced via isoflurane through the PI3K/AKT/GSK-3β pathway
by: Wang R, et al.
Published: (2019-02-01)

GSK-3β and Memory Formation
by: Akihiko eTakashima
Published: (2012-04-01)

Evaluation of the effect of GSK-3β on liver cancer based on the PI3K/AKT pathway
by: Jiageng Guo, et al.
Published: (2024-08-01)

A High-Carbohydrate Diet Induces Cognitive Impairment and Promotes Amyloid Burden and Tau Phosphorylation via PI3K/Akt/GSK-3β Pathway in db/db Mice
by: Jialu Xu, et al.
Published: (2024-07-01)

Tanshinone IIA Regulates Synaptic Plasticity in Mg2+-Free-Induced Epileptic Hippocampal Neurons via the PI3K/Akt Signaling Pathway
by: Meile Ma, et al.
Published: (2024-03-01)

New insights into the role of GSK-3β in the brain: from neurodegenerative disease to tumorigenesis
by: Shenjin Lai, et al.
Published: (2023-12-01)

High frequency repetitive transcranial magnetic stimulation alleviates cognitive deficits in 3xTg-AD mice by modulating the PI3K/Akt/GLT-1 axis
by: Huan Cao, et al.
Published: (2022-08-01)

Effects of DPP4 Inhibitors as Neuroprotective Drug on Cognitive Impairment in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis and Systematic Review
by: Yuting Yuan, et al.
Published: (2024-01-01)

Different Spectrophotometric Methods for Simultaneous Determination of Trelagliptin and Its Acid Degradation Product
by: Shereen Mowaka, et al.
Published: (2018-01-01)

A pivotal role of GSK-3 in synaptic plasticity
by: Clarrisa A Bradley, et al.
Published: (2012-02-01)

Post-stroke cognitive impairment and synaptic plasticity: A review about the mechanisms and Chinese herbal drugs strategies
by: Xiansu Chi, et al.
Published: (2023-03-01)

Piperine improves the sensitivity of osteosarcoma cells to doxorubicin by inducing apoptosis and inhibiting the PI3K/AKT/GSK-3β pathway
by: Yubin Qi, et al.
Published: (2023-03-01)

Knockdown of FANCI suppresses hepatocellular carcinoma development via the PI3K/Akt/GSK-3β pathway
by: Ziwei Yin, et al.
Published: (2025-02-01)

Schisandrin A Attenuates Diabetic Nephropathy via EGFR/AKT/GSK3β Signaling Pathway Based on Network Pharmacology and Experimental Validation
by: Pengyu Wang, et al.
Published: (2024-08-01)

Kukoamine A activates Akt/GSK-3β signaling pathway to inhibit oxidative stress and relieve myocardial ischemia-reperfusion injury
by: Han Xu, et al.
Published: (2022-07-01)

Opposite Epigenetic Associations With Alcohol Use and Exercise Intervention
by: Jiayu Chen, et al.
Published: (2018-11-01)

Trafficking and effect of released DNA on cGAS-STING signaling pathway and cardiovascular disease
by: Zimo Zhou, et al.
Published: (2023-12-01)

Sulforaphane Ameliorates the Intestinal Injury in Necrotizing Enterocolitis by Regulating the PI3K/Akt/GSK-3β Signaling Pathway
by: Zhong-Kun Bao, et al.
Published: (2022-01-01)

Discovery of an evodiamine derivative for PI3K/AKT/GSK3β pathway activation and AD pathology improvement in mouse models
by: Shuo Pang, et al.
Published: (2023-01-01)

Neurogranin as an important regulator in swimming training to improve the spatial memory dysfunction of mice with chronic cerebral hypoperfusion
by: Huawei Lin, et al.
Published: (2023-01-01)

Selenium Enhances the Growth of Bovine Endometrial Stromal Cells by PI3K/AKT/GSK-3β and Wnt/β-Catenin Pathways
by: Junsheng Dong, et al.
Published: (2024-12-01)

Neuroprotective Effects of Salidroside in the MPTP Mouse Model of Parkinson’s Disease: Involvement of the PI3K/Akt/GSK3β Pathway
by: Wei Zhang, et al.
Published: (2016-01-01)

Kaempferide Protects against Myocardial Ischemia/Reperfusion Injury through Activation of the PI3K/Akt/GSK-3β Pathway
by: Dong Wang, et al.
Published: (2017-01-01)

Gypenosides exert cardioprotective effects by promoting mitophagy and activating PI3K/Akt/GSK-3β/Mcl-1 signaling
by: Yizhe Zheng, et al.
Published: (2024-06-01)

Icariin protects against sodium azide—induced neurotoxicity by activating the PI3K/Akt/GSK-3β signaling pathway
by: Ying Zhang, et al.
Published: (2020-04-01)

MALAT1 promotes platelet activity and thrombus formation through PI3k/Akt/GSK-3β signalling pathway
by: Jing Jiang, et al.

Aldose reductase inhibition prevents allergic airway remodeling through PI3K/AKT/GSK3β pathway in mice.
by: Umesh C S Yadav, et al.
Published: (2013-01-01)

GSK3B inhibition reduced cervical cancer cell proliferation and migration by modulating the PI3K/Akt signaling pathway and epithelial-to-mesenchymal transition
by: Yanhong Zheng, et al.
Published: (2024-08-01)

Resveratrol Combined with 17β-Estradiol Prevents IL-1β Induced Apoptosis in Human Nucleus Pulposus Via The PI3K/AKT/Mtor and PI3K/AKT/GSK-3β Pathway
by: Xiaoliang Bai, et al.
Published: (2021-07-01)

Repeated Restraint Stress Led to Cognitive Dysfunction by NMDA Receptor-Mediated Hippocampal CA3 Dendritic Spine Impairments in Juvenile Sprague-Dawley Rats
by: Dong-sheng Sun, et al.
Published: (2020-10-01)

Protective Effect of Minocycline against Ketamine-induced Injury in Neural Stem Cell: Involvement of PI3K/Akt and Gsk-3 beta Pathway
by: Yang Lu, et al.
Published: (2016-12-01)

Anti-diabetic effect of Ornithogalum caudatum Jacq. polysaccharides via the PI3K/Akt/GSK-3β signaling pathway and regulation of gut microbiota
by: Xue-liang Zhao, et al.
Published: (2023-10-01)

Cognitive–exercise dual-task intervention ameliorates cognitive decline in natural aging rats via inhibiting the promotion of LncRNA NEAT1/miR-124–3p on caveolin-1-PI3K/Akt/GSK3β Pathway
by: Tiancong Li, et al.
Published: (2023-10-01)

Dysfunctional synaptic pruning by microglia correlates with cognitive impairment in sleep-deprived mice: Involvement of CX3CR1 signaling
by: Lu Wang, et al.
Published: (2023-07-01)

Aerobic Exercise Regulates Apoptosis through the PI3K/Akt/GSK-3β Signaling Pathway to Improve Cognitive Impairment in Alzheimer’s Disease Mice
by: Yan Peng, et al.
Published: (2022-01-01)