The Cell-Cycle Regulatory Protein p21<sup>CIP1/WAF1</sup> Is Required for Cytolethal Distending Toxin (Cdt)-Induced Apoptosis
The <i>Aggregatibacter actinomycetemcomitans</i> cytolethal distending toxin (Cdt) induces lymphocytes to undergo cell-cycle arrest and apoptosis; toxicity is dependent upon the active Cdt subunit, CdtB. We now demonstrate that p21<sup>CIP1/WAF1</sup> is critical to Cdt-induc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-01-01
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| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/9/1/38 |