Adipose Tissue in Persons With HIV Is Enriched for CD4+ T Effector Memory and T Effector Memory RA+ Cells, Which Show Higher CD69 Expression and CD57, CX3CR1, GPR56 Co-expression With Increasing Glucose Intolerance

Adipose Tissue in Persons With HIV Is Enriched for CD4+ T Effector Memory and T Effector Memory RA+ Cells, Which Show Higher CD69 Expression and CD57, CX3CR1, GPR56 Co-expression With Increasing Glucose Intolerance

Chronic T cell activation and accelerated immune senescence are hallmarks of HIV infection, which may contribute to the increased risk of cardiometabolic diseases in people living with HIV (PLWH). T lymphocytes play a central role in modulating adipose tissue inflammation and, by extension, adipocyt...

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Bibliographic Details
Main Authors: Celestine N. Wanjalla, Wyatt J. McDonnell, Louise Barnett, Joshua D. Simmons, Briana D. Furch, Morgan C. Lima, Beverly O. Woodward, Run Fan, Ye Fei, Paxton G. Baker, Ramesh Ram, Mark A. Pilkinton, Mona Mashayekhi, Nancy J. Brown, Simon A. Mallal, Spyros A. Kalams, John R. Koethe
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
HIV—human immunodeficiency virus
adipose tissue
diabetes mellitus
TEMRA
T effector memory cells
GPR56
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00408/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00408/full

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