Protection of Mice against Experimental Cryptococcosis by Synthesized Peptides Delivered in Glucan Particles

Protection of Mice against Experimental Cryptococcosis by Synthesized Peptides Delivered in Glucan Particles

ABSTRACT The high global burden of cryptococcosis has made development of a protective vaccine a public health priority. We previously demonstrated that a vaccine composed of recombinant Cryptococcus neoformans chitin deacetylase 2 (Cda2) delivered in glucan particles (GPs) protects BALB/c and C57BL...

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Bibliographic Details
Main Authors: Charles A. Specht, E. Jane Homan, Chrono K. Lee, Zhongming Mou, Christina L. Gomez, Maureen M. Hester, Ambily Abraham, Florentina Rus, Gary R. Ostroff, Stuart M. Levitz
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:mBio
Subjects:
CD4 T cells
Cryptococcus neoformans
immunoinformatics
MHC class II
fungal vaccine
glucan particles
Online Access:https://journals.asm.org/doi/10.1128/mbio.03367-21

Internet

https://journals.asm.org/doi/10.1128/mbio.03367-21

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