Computational Prediction of Inhibitors and Inducers of the Major Isoforms of Cytochrome P450

Computational Prediction of Inhibitors and Inducers of the Major Isoforms of Cytochrome P450

Human cytochrome P450 enzymes (CYPs) are heme-containing monooxygenases. This superfamily of drug-metabolizing enzymes is responsible for the metabolism of most drugs and other xenobiotics. The inhibition of CYPs may lead to drug–drug interactions and impair the biotransformation of drugs. CYP induc...

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Bibliographic Details
Main Authors: Anastassia Rudik, Alexander Dmitriev, Alexey Lagunin, Dmitry Filimonov, Vladimir Poroikov
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
CYP
inhibitors
inducers
(Q)SAR models
PASS
GUSAR
Online Access:https://www.mdpi.com/1420-3049/27/18/5875

Internet

https://www.mdpi.com/1420-3049/27/18/5875

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