A CRISPR endonuclease gene drive reveals distinct mechanisms of inheritance bias

A CRISPR endonuclease gene drive reveals distinct mechanisms of inheritance bias

CRISPR/Cas gene drives can bias transgene inheritance through different mechanisms. Here the authors use gene linkage to show that in males inheritance bias of wGDe did not occur by homing, rather through increased propagation of the donor drive element.

Bibliographic Details
Main Authors: Sebald A. N. Verkuijl, Estela Gonzalez, Ming Li, Joshua X. D. Ang, Nikolay P. Kandul, Michelle A. E. Anderson, Omar S. Akbari, Michael B. Bonsall, Luke Alphey
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34739-y

Internet

https://doi.org/10.1038/s41467-022-34739-y

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