TGFβ1‐induced beta‐site APP‐cleaving enzyme 2 upregulation promotes tumorigenesis through the NF‐κB signalling pathway in human gliomas

TGFβ1‐induced beta‐site APP‐cleaving enzyme 2 upregulation promotes tumorigenesis through the NF‐κB signalling pathway in human gliomas

Gliomas are the most common primary malignant tumours of the central nervous system, and new molecular biomarkers are urgently needed for diagnosis and targeted therapy. Here, we report that increased beta‐site APP‐cleaving enzyme 2 (BACE2) expression is associated with increases in the grade of hum...

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Bibliographic Details
Main Authors: Huizhi Wang, Zihang Chen, Shaobo Wang, Xiao Gao, Mingyu Qian, Wei Qiu, Zongpu Zhang, Shouji Zhang, Yanhua Qi, Xiaopeng Sun, Hao Xue, Xing Guo, Rongrong Zhao, Gang Li
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Molecular Oncology
Subjects:
BACE2
cell cycle
EMT
glioma
NF‐κB signalling
TGFβ signalling
Online Access:https://doi.org/10.1002/1878-0261.12623

Internet

https://doi.org/10.1002/1878-0261.12623

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